The most potent form and most used application of testosterone.
A great option for men who desire a higher level of hormone levels.
Testosterone was the first ever synthesized anabolic steroid, and testosterone cypionate is a slow-
acting, long-ester, oil-based injectable testosterone compound that is commonly prescribed for the
treatment of hypogonadism – low testosterone levels and various related symptoms in males.
Testosterone cypionate first appeared on the U.S. prescription drug market during the early 1950’s, as
Depo-Testosterone by Upjohn, now Pharmacia & Upjohn. Due to testosterone cypionate’s vast similarity
to the earlier released and slightly longer testosterone enanthate, it has received only limited global
availability and is often identified as an American medication.
Testosterone is the primary androgen found in the body. Endogenous testosterone is synthesized by
cells in the testis, ovary, and adrenal cortex. Therapeutically, testosterone is used in the management of
hypogonadism, either congenital or acquired. Testosterone is also the most effective exogenous
androgen for the palliative treatment of carcinoma of the breast in postmenopausal women.
Testosterone was in use in 1938 and approved by the FDA in 1939. Anabolic steroids, derivatives of
testosterone, have been used illicitly and are now controlled substances. Testosterone, like many
anabolic steroids, was classified as a controlled substance in 1991. Testosterone is administered
parenterally in regular and delayed-release (depot) dosage forms. In September 1995, the FDA initially
approved testosterone transdermal patches (Androderm); many transdermal forms and brands are now
available including implants, gels, and topical solutions. A testosterone buccal system, Striant, was FDA
approved in July 2003; the system is a mucoadhesive product that adheres to the buccal mucosa and
provides a controlled and sustained release of testosterone. In May 2014, the FDA approved an
intranasal gel formulation (Natesto). A transdermal patch (Intrinsa) for hormone replacement in women
is under investigation; the daily dosages used in women are much lower than for products used in
males. The FDA ruled in late 2004 that it would delay the approval of Intrinsa women's testosterone
patch and has required more data regarding safety, especially in relation to cardiovascular and breast
The Cypionate Ester: An ester is any of a class of organic compounds that react with water to produce
alcohols and organic or inorganic acids. Most esters are derived from carboxylic acids, and injectable
testosterone is typically administered along with one or multiple esters. The addition of a carbon chain
(ester) attached to the testosterone molecule controls how soluble it will be once inside the
bloodstream. The smaller the carbon chain, the shorter the ester, and the more soluble the medication.
A small/short will have a shorter half life – a repeating cycle of a medication’s time within the body. The
inverse is true of long carbon chains, like cypionate, which both act slowly upon the body and evacuates
the body at a similar rate.